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1

Effects of the dual PPAR-α/γ agonist aleglitazar on glycaemic control and organ protection in the Zucker diabetic fatty rat

Bénardeau, A., Verry, P., Atzpodien, E.-A., Funk, J. M., Meyer, M., Mizrahi, J., Winter, M., Wright, M. B., Uhles, S., Sebokova, E.

Journal:

Diabetes, Obesity and Metabolism

Year:

2013

Language:

english

File:

PDF, 1.45 MB

english, 2013

2

6-Alkoxy-5-aryl-3-pyridinecarboxamides, a New Series of Bioavailable Cannabinoid Receptor Type 1 (CB1) Antagonists Including Peripherally Selective Compounds

Röver, Stephan, Andjelkovic, Mirjana, Bénardeau, Agnès, Chaput, Evelyne, Guba, Wolfgang, Hebeisen, Paul, Mohr, Susanne, Nettekoven, Matthias, Obst, Ulrike, Richter, Wolfgang F., Ullmer, Christoph, Wal

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.29 MB

english, 2013

3

Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists

Uwe Grether, Agnes Bénardeau, Jörg Benz, Alfred Binggeli, Denise Blum, Hans Hilpert, Bernd Kuhn, Hans Peter Märki, Markus Meyer, Peter Mohr, Kurt Püntener, Susanne Raab, Armin Ruf, Daniel Schlatter

Journal:

Year:

2009

Language:

english

File:

PDF, 357 KB

english, 2009

4

Inside Cover: Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists (ChemMedChem 6/2009)

Uwe Grether, Agnes Bénardeau, Jörg Benz, Alfred Binggeli, Denise Blum, Hans Hilpert, Bernd Kuhn, Hans Peter Märki, Markus Meyer, Peter Mohr, Kurt Püntener, Susanne Raab, Armin Ruf, Daniel Schlatter

Journal:

Year:

2009

Language:

english

File:

PDF, 439 KB

english, 2009

5

Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes

Agnes Bénardeau, Jörg Benz, Alfred Binggeli, Denise Blum, Markus Boehringer, Uwe Grether, Hans Hilpert, Bernd Kuhn, Hans Peter Märki, Markus Meyer, Kurt Püntener, Susanne Raab, Armin Ruf, Daniel Schla

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 523 KB

english, 2009

6

Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of Type-2 diabetes

Eric Kitas, Peter Mohr, Bernd Kuhn, Paul Hebeisen, Hans Peter Wessel, Wolfgang Haap, Armin Ruf, Jörg Benz, Catherine Joseph, Walter Huber, Ruben Alvarez Sanchez, Axel Paehler, Agnes Benardeau, Marcel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 2.81 MB

english, 2010

7

Synthesis and biological evaluation of novel hexahydro-pyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT2C receptor agonists

Hans G.F. Richter, D.R. Adams, A. Benardeau, M.J. Bickerdike, J.M. Bentley, T.J. Blench, I.A. Cliffe, C. Dourish, P. Hebeisen, G.A. Kennett, A.R. Knight, C.S. Malcolm, P. Mattei, A. Misra, J. Mizrahi,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 145 KB

english, 2006

8

Effects of aleglitazar, a balanced dual peroxisome proliferator-activated receptor α/γ agonist on glycemic and lipid parameters in a primate model of the metabolic syndrome

Barbara C Hansen, Xenia T Tigno, Agnes Bénardeau, Markus Meyer, Elena Sebokova, Jacques Mizrahi

Journal:

Cardiovascular Diabetology

Year:

2011

Language:

english

File:

PDF, 433 KB

english, 2011

9

Pharmacological properties of Cav3.2, a low voltage-activated Ca2+channel cloned from human heart

Loïc Perchenet, Agnès Bénardeau, Eric A. Ertel

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2000

Language:

english

File:

PDF, 200 KB

english, 2000

10

Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists

S. Röver, D.R. Adams, A. Bénardeau, J.M. Bentley, M.J. Bickerdike, A. Bourson, I.A. Cliffe, P. Coassolo, J.E.P. Davidson, C.T. Dourish, P. Hebeisen, G.A. Kennett, A.R. Knight, C.S. Malcolm, P. Mattei,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 179 KB

english, 2005

11

Taspoglutide, a novel human once-weekly analogue of glucagon-like peptide-1, improves glucose homeostasis and body weight in the Zucker diabetic fatty rat

E. Sebokova, A. Bénardeau, U. Sprecher, S. Sewing, L. Tobalina, C. Migliorini

Journal:

Diabetes, Obesity and Metabolism

Year:

2010

Language:

english

File:

PDF, 597 KB

english, 2010

12

Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo

S. Uhles, H. Wang, A. Bénardeau, M. Prummer, M. Brecheisen, S. Sewing, L. Tobalina, D. Bosco, C. B. Wollheim, C. Migliorini, E. Sebokova

Journal:

Diabetes, Obesity and Metabolism

Year:

2011

Language:

english

File:

PDF, 1.49 MB

english, 2011

13

Dalcetrapib: no off-target toxicity on blood pressure or on genes related to the renin-angiotensin-aldosterone system in rats

ESG Stroes, JJP Kastelein, A Bénardeau, O Kuhlmann, D Blum, LA Campos, RG Clerc, EJ Niesor

Journal:

British Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 516 KB

english, 2009

14

Quantitative Body Composition Analysis in Awake Mice and Rats by Magnetic Resonance Relaxometry

Basil Künnecke, Philippe Verry, Agnès Bénardeau, Markus Von Kienlin

Journal:

Year:

2004

Language:

english

File:

PDF, 194 KB

english, 2004

15

Primary Culture of Human Atrial Myocytes is Associated with the Appearance of Structural and Functional Characteristics of Immature Myocardium

Agnès Bénardeau, Stéphane N. Hatem, Catherine Rücker-Martin, Sophie Tessier, Sylvie Dinanian, Jane-Lyse Samuel, Edouard Coraboeuf, Jean-Jaques Mercadier

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1997

Language:

english

File:

PDF, 811 KB

english, 1997

16

Combined activation of PPAR-gamma and PPAR-alpha reduces the negative effects of PPAR-gamma agonism on bone and may attenuate PPAR-gamma-mediated loss of bone strength

S. Smith⁎, R. Samadfam, L. Chouinard, M. Awori, A. Benardeau, F. Bauss, E. Sebokova, M.B. Wright

Journal:

Year:

2012

Language:

english

File:

PDF, 74 KB

english, 2012

17

COMPARISON OF EFFECTS OF TORCETRAPIB AND RO4607381/JTT-705 ON BLOOD PRESSURE AND TISSUE EXPRESSION OF RENIN-ANGIOTENSIN SYSTEM-RELATED GENES IN RATS

Kastelein, J.J., Stroes, E.S., Benardeau, A., Blum, D., Clerc, R.G., Campos, L., Niesor, E.J.

Journal:

Atherosclerosis Supplements

Year:

2008

Language:

english

File:

PDF, 71 KB

english, 2008

18

Benzodioxoles: Novel Cannabinoid-1 Receptor Inverse Agonists for the Treatment of Obesity

Alig, Leo, Alsenz, Jochem, Andjelkovic, Mirjana, Bendels, Stefanie, Bénardeau, Agnès, Bleicher, Konrad, Bourson, Anne, David-Pierson, Pascale, Guba, Wolfgang, Hildbrand, Stefan, Kube, Dagmar, Lübbers,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.56 MB

english, 2008

19

Effects of pioglitazone and fenofibrate co-administration on bone biomechanics and histomorphometry in ovariectomized rats

Smith, Susan Y., Samadfam, Rana, Chouinard, Luc, Awori, Malaika, Bénardeau, Agnes, Bauss, Frieder, Guldberg, Robert E., Sebokova, Elena, Wright, Matthew B.

Journal:

Journal of Bone and Mineral Metabolism

Year:

2015

Language:

english

File:

PDF, 1.15 MB

english, 2015

20

The T-Type Ca2+ Channel Blocker Mibefradil Prevents the Development of a Substrate for Atrial Fibrillation by Tachycardia-Induced Atrial Remodeling in Dogs

Fareh, S., Benardeau, A., Thibault, B., Nattel, S.

Journal:

Year:

1999

Language:

english

File:

PDF, 572 KB

english, 1999

21

Combination treatment with pioglitazone and fenofibrate attenuates pioglitazone-mediated acceleration of bone loss in ovariectomized rats

Samadfam, R., Awori, M., Benardeau, A., Bauss, F., Sebokova, E., Wright, M., Smith, S. Y.

Journal:

Journal of Endocrinology

Year:

2012

Language:

english

File:

PDF, 217 KB

english, 2012

22

Contrasting Efficacy of Dofetilide in Differing Experimental Models of Atrial Fibrillation

Li, D., Benardeau, A., Nattel, S.

Journal:

Year:

2000

Language:

english

File:

PDF, 519 KB

english, 2000

23

Effects of verapamil on atrial fibrillation and its electrophysiological determinants in dogs

Journal:

Cardiovascular Research

Year:

2001

Language:

english

File:

PDF, 688 KB

english, 2001

24

Semiautomated quantitative image analysis of glomerular immunohistochemistry markers desmin, vimentin, podocin, synaptopodin and WT-1 in acute and chronic rat kidney disease models

Funk, J., Ott, V., Herrmann, A., Rapp, W., Raab, S., Riboulet, W., Vandjour, A., Hainaut, E., Benardeau, A., Singer, T., Jacobsen, B.

Journal:

Histochemistry and Cell Biology

Year:

2016

Language:

english

File:

PDF, 1.76 MB

english, 2016

25

5-HT2C Receptor Agonists for the Treatment of Obesity. Biological and Chemical Adventures

Adams, David, Bénardeau, Agnès, Bickerdike, Mike J., Bentley, Jon M., Bissantz, Caterina, Bourson, Anne, Cliffe, Ian A., Hebeisen, Paul, Kennett, Guy A., Knight, Antony R., Malcolm, Craig S., Mizrahi,

Journal:

CHIMIA International Journal for Chemistry

Year:

2004

Language:

english

File:

PDF, 3.01 MB

english, 2004

26

Mechanisms underlying off-target effects of the cholesteryl ester transfer protein inhibitor torcetrapib involve L-type calcium channels

Clerc, Roger G, Stauffer, Andrea, Weibel, Franziska, Hainaut, Emmanuelle, Perez, Anne, Hoflack, Jean-Christophe, Bénardeau, Agnès, Pflieger, Philippe, Garriz, Jose MR, Funder, John W, Capponi, Alessan

Journal:

Journal of Hypertension

Year:

2010

Language:

english

File:

PDF, 441 KB

english, 2010

27

Animal Models of Diabetic Macrovascular Complications: Key Players in the Development of New Therapeutic Approaches

Heinonen, Suvi E., Genové, Guillem, Bengtsson, Eva, Hübschle, Thomas, Åkesson, Lina, Hiss, Katrin, Benardeau, Agnes, Ylä-Herttuala, Seppo, Jönsson-Rylander, Ann-Cathrine, Gomez, Maria F.

Journal:

Journal of Diabetes Research

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

28

The Impact of the Nitric Oxide (NO)/Soluble Guanylyl Cyclase (sGC) Signaling Cascade on Kidney Health and Disease: A Preclinical Perspective

Krishnan, Shalini, Kraehling, Jan, Eitner, Frank, Bénardeau, Agnès, Sandner, Peter

Journal:

International Journal of Molecular Sciences

Year:

2018

Language:

english

File:

PDF, 1.68 MB

english, 2018

29

Differential regulation of voltage-activated potassium currents in cultured human atrial myocytes

Hatem, S. N., Benardeau, A., Rucker-Martin, C., Samuel, J. L., Coraboeuf, E., Mercadier, J. J.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

1996

Language:

english

File:

PDF, 2.95 MB

english, 1996